In an experimentally-induced DTH model of MS, we examined mRNA and protein expression of a range of MMPs and of TNFalpha to establish the contribution that individual MMPs might make to the pathogenesis. In control rat brain, mRNA for all of the MMPs examined was detectable. However, by immunohistochemistry, only MMP-2 could be detected. In the DTH lesions, significant increases in the level of mRNA expression were observed for MMP-7, MMP-8, MMP-12, and TNFalpha. Where expression of MMP mRNA ...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
Matrix metalloproteinase expression in an experimentally-induced DTH model of multiple sclerosis in the rat CNS.
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record