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Matrix metalloproteinase expression in an experimentally-induced DTH model of multiple sclerosis in the rat CNS.

Abstract:

In an experimentally-induced DTH model of MS, we examined mRNA and protein expression of a range of MMPs and of TNFalpha to establish the contribution that individual MMPs might make to the pathogenesis. In control rat brain, mRNA for all of the MMPs examined was detectable. However, by immunohistochemistry, only MMP-2 could be detected. In the DTH lesions, significant increases in the level of mRNA expression were observed for MMP-7, MMP-8, MMP-12, and TNFalpha. Where expression of MMP mRNA ...

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Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
Journal of neuroimmunology More from this journal
Volume:
87
Issue:
1-2
Pages:
62-72
Publication date:
1998-07-01
DOI:
EISSN:
1872-8421
ISSN:
0165-5728
Language:
English
Keywords:
Pubs id:
pubs:383088
UUID:
uuid:223b4332-9587-4238-841a-65fa2ebbd53b
Local pid:
pubs:383088
Source identifiers:
383088
Deposit date:
2013-11-16

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