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Journal article

Matrix metalloproteinase expression in an experimentally-induced DTH model of multiple sclerosis in the rat CNS.

Abstract:

In an experimentally-induced DTH model of MS, we examined mRNA and protein expression of a range of MMPs and of TNFalpha to establish the contribution that individual MMPs might make to the pathogenesis. In control rat brain, mRNA for all of the MMPs examined was detectable. However, by immunohistochemistry, only MMP-2 could be detected. In the DTH lesions, significant increases in the level of mRNA expression were observed for MMP-7, MMP-8, MMP-12, and TNFalpha. Where expression of MMP mRNA ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
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Journal:
Journal of neuroimmunology
Volume:
87
Issue:
1-2
Pages:
62-72
Publication date:
1998-07-05
DOI:
EISSN:
1872-8421
ISSN:
0165-5728
URN:
uuid:223b4332-9587-4238-841a-65fa2ebbd53b
Source identifiers:
383088
Local pid:
pubs:383088

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