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Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error

Abstract:

Corneal curvature, a highly heritable trait, is a key clinical endophenotype for myopia - a major cause of visual impairment and blindness in the world. Here we present a trans-ethnic meta-analysis of corneal curvature GWAS in 44,042 individuals of Caucasian and Asian with replication in 88,218 UK Biobank data. We identified 47 loci (of which 26 are novel), with population-specific signals as well as shared signals across ethnicities. Some identified variants showed precise scaling in corneal...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s42003-020-0802-y

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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Population Health
Oxford college:
St Cross College
Role:
Author
ORCID:
0000-0002-2374-9204
Publisher:
Springer Nature
Journal:
Communications Biology More from this journal
Volume:
3
Article number:
133
Place of publication:
England
Publication date:
2020-03-19
Acceptance date:
2020-01-24
DOI:
EISSN:
2399-3642
Pmid:
32193507
Language:
English
Keywords:
Pubs id:
1098756
Local pid:
pubs:1098756
Deposit date:
2020-07-28

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