Journal article

Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease

Abstract:: Identifying accurate biomarkers of cognitive decline is essential for advancing early diagnosis and prevention therapies in Alzheimer's disease. The Alzheimer's disease DREAM Challenge was designed as a computational crowdsourced project to benchmark the current state-of-the-art in predicting cognitive outcomes in Alzheimer's disease based on high dimensional, publicly available genetic and structural imaging data. This meta-analysis failed to identify a meaningful predictor developed from either data modality, suggesting that alternate approaches should be considered for prediction of cognitive performance.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Allen, G., Amoroso, N., Anghel, C., & Lovestone, S. (2016). Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease. Alzheimer's & Dementia, 12(6), 645–653.

MLA Style

Allen, G., et al. “Crowdsourced Estimation of Cognitive Decline and Resilience in Alzheimer's Disease.” Alzheimer's & Dementia, vol. 12, no. 6, Elsevier, 2016, pp. 645–53.

Chicago Style

Allen, G, N Amoroso, C Anghel, and S Lovestone. 2016. “Crowdsourced Estimation of Cognitive Decline and Resilience in Alzheimer's Disease.” Alzheimer's & Dementia 12 (6): 645–53.
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Files:: 1-s2.0-S1552526016000819-main.pdf

(Preview, Version of record, pdf, 1.6MB, Terms of use)

Publisher copy:: 10.1016/j.jalz.2016.02.006

Authors

+ Allen, G More by this author

Role:: Author

+ Amoroso, N More by this author

Role:: Author

+ Anghel, C More by this author

Role:: Author

+ Lovestone, S More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Psychiatry
Role:: Author

Publisher:: Elsevier
Journal:: Alzheimer's & Dementia More from this journal
Volume:: 12
Issue:: 6
Pages:: 645-653
Publication date:: 2016-04-11
DOI:: 10.1016/j.jalz.2016.02.006
EISSN:: 1552-5279
ISSN:: 1552-5260
Pmid:: 27079753

Language:: English
Keywords:: Big data

Biomarkers

Cognitive decline

Crowdsource

Bioinformatics

Imaging

Genetics

Azheimer's disease
Pubs id:: pubs:616695
UUID:: uuid:22351104-8cc2-424b-bf56-4fb9db6362a3
Local pid:: pubs:616695
Source identifiers:: 616695
Deposit date:: 2017-07-24

Terms of use

Copyright holder:: © 2016 Allen, et al
Copyright date:: 2016
Notes:: This is an open access article under the CC BY-NC-ND
license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Licence:: CC Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)

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