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Journal article

A common human TLR1 polymorphism regulates the innate immune response to lipopeptides.

Abstract:

Toll-like receptors (TLR) are critical mediators of the immune response to pathogens and human polymorphisms in this gene family regulate inflammatory pathways and are associated with susceptibility to infection. Lipopeptides are present in a wide variety of microbes and stimulate immune responses through TLR1/2 or TLR2/6 heterodimers. It is not currently known whether polymorphisms in TLR1 regulate the innate immune response. We stimulated human whole blood with triacylated lipopeptide, a li...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200737034

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Journal:
European journal of immunology More from this journal
Volume:
37
Issue:
8
Pages:
2280-2289
Publication date:
2007-08-01
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Language:
English
Keywords:
Pubs id:
pubs:92780
UUID:
uuid:22320a6f-0b48-480a-87a9-365efc2d7431
Local pid:
pubs:92780
Source identifiers:
92780
Deposit date:
2012-12-19

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