Journal article icon

Journal article

Intramuscular artesunate for severe malaria in African children: a multicenter randomized controlled trial

Abstract:

Background Current artesunate (ARS) regimens for severe malaria are complex. Once daily intramuscular (i.m.) injection for 3 d would be simpler and more appropriate for remote health facilities than the current WHO-recommended regimen of five intravenous (i.v.) or i.m. injections over 4 d. We compared both a three-dose i.m. and a three-dose i.v. parenteral ARS regimen with the standard five-dose regimen using a non-inferiority design (with non-inferiority margins of 10%).<...>

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pmed.1001938

Authors


Expand authors...
Central African Network on Tuberculosis, HIV/AIDS and Malaria More from this funder
German Center for Infection Research More from this funder
Expand funders...
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Medicine Journal website
Volume:
13
Issue:
1
Pages:
Article: e1001938
Publication date:
2016-01-12
Acceptance date:
2015-12-02
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
Pubs id:
pubs:586261
URN:
uri:21f421bf-16e6-4350-8388-152c463d2a26
UUID:
uuid:21f421bf-16e6-4350-8388-152c463d2a26
Local pid:
pubs:586261

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP