- Abstract:
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Background Current artesunate (ARS) regimens for severe malaria are complex. Once daily intramuscular (i.m.) injection for 3 d would be simpler and more appropriate for remote health facilities than the current WHO-recommended regimen of five intravenous (i.v.) or i.m. injections over 4 d. We compared both a three-dose i.m. and a three-dose i.v. parenteral ARS regimen with the standard five-dose regimen using a non-inferiority design (with non-inferiority margins of 10%).<...>
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
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(pdf, 2.0MB)
-
- Publisher copy:
- 10.1371/journal.pmed.1001938
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Medicine Journal website
- Volume:
- 13
- Issue:
- 1
- Pages:
- Article: e1001938
- Publication date:
- 2016-01-12
- Acceptance date:
- 2015-12-02
- DOI:
- EISSN:
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1549-1676
- ISSN:
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1549-1277
- Pubs id:
-
pubs:586261
- URN:
-
uri:21f421bf-16e6-4350-8388-152c463d2a26
- UUID:
-
uuid:21f421bf-16e6-4350-8388-152c463d2a26
- Local pid:
- pubs:586261
- Copyright holder:
- Kremsner et al.
- Copyright date:
- 2016
- Notes:
- © 2016 Kremsner et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Journal article
Intramuscular artesunate for severe malaria in African children: a multicenter randomized controlled trial
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Central African Network on Tuberculosis, HIV/AIDS and Malaria
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German Center for Infection Research
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