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Intramuscular artesunate for severe malaria in African children: a multicenter randomized controlled trial

Abstract:

Background Current artesunate (ARS) regimens for severe malaria are complex. Once daily intramuscular (i.m.) injection for 3 d would be simpler and more appropriate for remote health facilities than the current WHO-recommended regimen of five intravenous (i.v.) or i.m. injections over 4 d. We compared both a three-dose i.m. and a three-dose i.v. parenteral ARS regimen with the standard five-dose regimen using a non-inferiority design (with non-inferiority margins of 10%).<...>

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


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Name:
Federal Ministry of Education and Research
Grant:
BMBF grant 01KA1011
More from this funder
Name:
European and Developing Countries Clinical Trials
Grant:
CT.2004.31070.001
More from this funder
Name:
Medical Research Council
Grant:
MC_UP_A900_1118
More from this funder
Name:
Deutsche Forschungsgemeinschaft
Grant:
KE 1629/1-1
More from this funder
Name:
German Center for Infection Research
Publisher:
Public Library of Science
Journal:
PLoS Medicine More from this journal
Volume:
13
Issue:
1
Article number:
e1001938
Publication date:
2016-01-12
Acceptance date:
2015-12-02
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
Pmid:
26757276
Language:
English
Keywords:
Pubs id:
pubs:586261
UUID:
uuid:21f421bf-16e6-4350-8388-152c463d2a26
Local pid:
pubs:586261
Source identifiers:
586261
Deposit date:
2018-10-02

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