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Tight coupling of astrocyte pH dynamics to epileptiform activity revealed by genetically-encoded pH sensors

Abstract:

Astrocytes can both sense and shape the evolution of neuronal network activity and are known to possess unique ion regulatory mechanisms. Here we explore the relationship between astrocytic intracellular pH dynamics and the synchronous network activity that occurs during seizure-like activity. By combining confocal and two-photon imaging of genetically-encoded pH reporters with simultaneous electrophysiological recordings, we perform pH measurements in defined cell populations and relate thes...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
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Name:
Medical Research Council
Grant:
G0601503
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Name:
Oxford Stem Cell Institute
Publisher:
Society for Neuroscience
Journal:
Journal of Neuroscience More from this journal
Volume:
36
Issue:
26
Pages:
7002-7013
Publication date:
2016-06-01
Acceptance date:
2016-05-23
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
Keywords:
Pubs id:
pubs:625734
UUID:
uuid:21f24ce3-ea40-49a9-b3fb-706a1e29d31d
Local pid:
pubs:625734
Source identifiers:
625734
Deposit date:
2016-06-06

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