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Journal article

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

Abstract:

CD4+ T cells are central mediators of autoimmune pathology; however, the definition of their key effector functions in specific autoimmune diseases remains limited. Pathogenic CD4+ T cells within affected tissues may be identified by expression of markers of recent activation1. We applied this approach to joint tissue in rheumatoid arthritis (RA), a chronic immune7ediated arthritis that affects up to 1% of the population2. Utilizing mass cytometry to detect activated T cells in RA synovial ti...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nature20810

Authors


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Name:
Seventh Framework Programme
Grant:
305549
More from this funder
Name:
Arthritis Research UK
Grant:
18547
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Name:
National Institutes of Health
Grant:
K01 AR066063
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Name:
Rheumatology Research Foundation
Publisher:
Nature Publishing Group
Journal:
Nature More from this journal
Volume:
542
Issue:
7639
Pages:
110-114
Publication date:
2017-02-01
Acceptance date:
2016-11-18
DOI:
ISSN:
0028-0836 and 1476-4687
Keywords:
Pubs id:
pubs:727900
UUID:
uuid:21d6d92e-4159-4ab3-8674-bd0fefc22b76
Local pid:
pubs:727900
Source identifiers:
727900
Deposit date:
2018-05-17

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