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Journal article

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

Abstract:

CD4+ T cells are central mediators of autoimmune pathology; however, the definition of their key effector functions in specific autoimmune diseases remains limited. Pathogenic CD4+ T cells within affected tissues may be identified by expression of markers of recent activation1. We applied this approach to joint tissue in rheumatoid arthritis (RA), a chronic immune7ediated arthritis that affects up to 1% of the population2. Utilizing mass cytometry to detect activated T cells in RA synovial ti...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/nature20810

Authors


Gurish, MF More by this author
Marshall, JL More by this author
Slowikowski, K More by this author
Fonseka, CY More by this author
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William Docken Inflammatory Autoimmune Disease Fund More from this funder
Mallinckrodt Foundation More from this funder
Doris Duke Charitable Foundation More from this funder
Rheumatology Research Foundation More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Journal website
Volume:
542
Issue:
7639
Pages:
110-114
Publication date:
2017-02-01
Acceptance date:
2016-11-18
DOI:
ISSN:
1476-4687 and 0028-0836
Pubs id:
pubs:727900
URN:
uri:21d6d92e-4159-4ab3-8674-bd0fefc22b76
UUID:
uuid:21d6d92e-4159-4ab3-8674-bd0fefc22b76
Local pid:
pubs:727900

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