Coarse-graining DNA for simulations of DNA nanotechnology.

Journal article

To simulate long time and length scale processes involving DNA it is necessary to use a coarse-grained description. Here we provide an overview of different approaches to such coarse-graining, focussing on those at the nucleotide level that allow the self-assembly processes associated with DNA nanotechnology to be studied. OxDNA, our recently-developed coarse-grained DNA model, is particularly suited to this task, and has opened up this field to systematic study by simulations. We illustrate some of the range of DNA nanotechnology systems to which the model is being applied, as well as the insights it can provide into fundamental biophysical properties of DNA.

Authors: Doye, J; Ouldridge, T; Louis, A; Romano, F; Šulc, P

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: RSC Publishing
• Journal: Physical chemistry chemical physics : PCCP
• Volume: 15
• Issue: 47
• Pages: 20395-20414
• Publication date: 2013-12-01
• DOI: 10.1039/c3cp53545b
• EISSN: 1463-9084
• ISSN: 1463-9076
• Language: English
• Keywords: Self-assembly (Chemistry); Simulation methods; Biophysics; Nanobiotechnology; OxDNA; Nucleotides; DNA
• Subjects: Nano-biotechnology; Biophysics