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EDH: Endothelium-dependent hyperpolarization and microvascular signaling.

Abstract:

Endothelium-dependent hyperpolarizing factor (EDHF) is a powerful vasodilator influence in small resistance arteries and thus an important modulator of blood pressure and flow. As the name suggests, EDHF was thought to describe a diffusible factor stimulating smooth muscle hyperpolarization (and thus vasodilatation). However, this idea has evolved with the recognition that a factor(s) can operate the spread of hyperpolarizing current from the endothelium to the vascular smooth muscle (VSM). A...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/apha.12649

Authors


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Institution:
University of Oxford
Oxford college:
Magdalen College
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
More from this funder
Name:
Royal Society
Funding agency for:
Garland, C
Grant:
Wolfson Research Merit Award
More from this funder
Name:
British Heart Foundation
Funding agency for:
Dora, K
Grant:
Senior Basic Science Research Fellow
More from this funder
Name:
Stiftelsen Nordisk Fysiologi
Publisher:
Wiley
Journal:
Acta Physiologica More from this journal
Volume:
219
Issue:
1
Pages:
152-161
Publication date:
2016-01-01
Acceptance date:
2016-01-06
DOI:
EISSN:
1748-1716
ISSN:
1748-1708
Pmid:
26752699
Language:
English
Keywords:
Pubs id:
pubs:589115
UUID:
uuid:21c481ec-3e9c-4ea8-9520-c5b6ec9ba9d1
Local pid:
pubs:589115
Source identifiers:
589115
Deposit date:
2017-04-22

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