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Assessment of selected media supplements to improve F/HN lentiviral vector production yields

Abstract:

The development of lentiviral-based therapeutics is challenged by the high cost of current Good Manufacturing Practices (cGMP) production. Lentiviruses are enveloped viruses that capture a portion of the host cell membrane during budding, which then constitutes part of the virus particle. This process might lead to lipid and protein depletion in the cell membrane and affect cell viability. Furthermore, growth in suspension also causes stresses that can affect virus production yields. To asses...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41598-017-07893-3

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Clinical Laboratory Sciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Clinical Laboratory Sciences
More by this author
Institution:
University of Oxford
Department:
University College
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Clinical Laboratory Sciences
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Funding agency for:
Gélinas, J-F
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Funding agency for:
Gélinas, J-F
Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Pages:
10198
Publication date:
2017-08-31
Acceptance date:
2017-05-31
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pubs id:
pubs:698713
URN:
uri:21930b5f-6703-4beb-990e-456962af688a
UUID:
uuid:21930b5f-6703-4beb-990e-456962af688a
Local pid:
pubs:698713

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