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The solvation structure of alprazolam

Abstract:

Alprazolam is a benzodiazepine that is commonly prescribed for the treatment of anxiety and other related disorders. Like other benzodiazepines, it is thought to exert its effect through interaction with GABAA receptors. However, it has also been described as a potent and selective protein interaction inhibitor of bromodomain and extra-terminal (BET) proteins. Indeed, the only crystal structure of alprazolam bound to a protein is a complex between alprazolam and the BRD4 bromodomain. The stru...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1039/c6cp02645a

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Name:
Engineering and Physical Sciences Research Council
Grant:
EP/J002615/1
Publisher:
Royal Society of Chemistry
Journal:
Physical Chemistry Chemical Physics More from this journal
Volume:
18
Issue:
32
Pages:
22416-22425
Publication date:
2016-08-01
Acceptance date:
2016-07-20
DOI:
EISSN:
1463-9084
ISSN:
1463-9076
Pmid:
27465367
Language:
English
Keywords:
Pubs id:
pubs:636404
UUID:
uuid:21794a43-1726-4a96-8b8f-22fd0c108f2f
Local pid:
pubs:636404
Source identifiers:
636404
Deposit date:
2016-09-20

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