Genetic and epigenetic basis of clonal advantage during the evolution of acute myeloid leukaemia

Thesis

Acute myeloid leukaemia (AML) is an aggressive malignant disorder of immature myeloid cells in the bone marrow. The outcome of older AML patients who are unfit for intensive chemotherapy remains dismal. Relapse, which is the main cause of mortality, occurs due to Darwinian clonal selection and persistence of leukaemia stem cells (LSCs) throughout treatment. Understanding the kinetics of clonal selection and the molecular mechanisms promoting LSC phenotypes is thus urgently required.

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Authors: Turkalj, S

• DOI: 10.5287/ora-ve7x4q0ar
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English