Journal article
Searching for the ideal triazole: investigating the 1,5-triazole as a charge neutral DNA backbone mimic
- Abstract:
- A novel triazole linkage that mimics the phosphodiester backbone in DNA was designed, synthesised and evaluated. Unlike previous work which utilised copper to form a 1,4 triazole linkage in the DNA backbone, a ruthenium catalyst was used to yield a 1,5 triazole. The artificial linkage was incorporated into a DNA backbone via a phosphoramidite building block using solid phase synthesis. The biophysical properties of DNA with a 1,5 triazole linkage in the backbone were evaluated by UV melting and circular dichroism and compared to DNA modified with previously reported 1,4 triazole linkages of various lengths.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, 522.8KB, Terms of use)
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- Publisher copy:
- 10.1016/j.tet.2019.130914
Authors
- Publisher:
- Elsevier
- Journal:
- Tetrahedron More from this journal
- Volume:
- 76
- Issue:
- 7
- Article number:
- 130914
- Publication date:
- 2019-12-31
- Acceptance date:
- 2019-12-21
- DOI:
- ISSN:
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0040-4020
- Language:
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English
- Keywords:
- Pubs id:
-
1083866
- Local pid:
-
pubs:1083866
- Deposit date:
-
2020-03-16
Terms of use
- Copyright holder:
- Elsevier Ltd.
- Copyright date:
- 2020
- Rights statement:
- © 2020 Elsevier Ltd. All rights reserved
- Notes:
- This is the accepted manuscript version of the article. The final version of the article is available from Elsevier at: https://doi.org/10.1016/j.tet.2019.130914
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