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Fission yeast Pds5 is required for accurate chromosome segregation and for survival after DNA damage or metaphase arrest.

Abstract:

Sister chromatid cohesion, which is established during the S phase of the eukaryotic cell cycle and persists until the onset of anaphase, is essential for the maintenance of genomic integrity. Cohesion requires the multi-protein complex cohesin, as well as a number of accessory proteins including Pds5/BIMD/Spo76. In the budding yeast Saccharomyces cerevisiae Pds5 is an essential protein that localises to chromosomes in a cohesin-dependent manner. Here we describe the characterisation in the f...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Journal of cell science
Volume:
115
Issue:
Pt 3
Pages:
587-598
Publication date:
2002-02-05
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:21589438-0369-4123-b3a8-1025ea349df3
Source identifiers:
2768
Local pid:
pubs:2768

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