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Journal article

A blood atlas of COVID-19 defines hallmarks of disease severity and specificity

Abstract:

Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete description of specific immune biomarkers. We present here a comprehensive multi-omic blood atlas for patients with varying COVID-19 severity in an integrated comparison with influenza and sepsis patients versus healthy volunteers. We identify immune signatures and correlates of host response. Hallmarks of disease severity involved cells, their inflammatory mediators and networks, including progenitor c...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Contributor
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Name:
Wellcome Trust
Grant:
204290/Z/16/Z
Publisher:
Cell Press
Journal:
Cell More from this journal
Volume:
185
Issue:
5
Pages:
916-938.e58
Publication date:
2022-01-20
Acceptance date:
2022-01-17
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Language:
English
Keywords:
Pubs id:
1233228
Local pid:
pubs:1233228
Deposit date:
2022-02-18

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