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Thesis

The effects of laser-assisted zona pellucida manipulations on embryo competency and the mechanisms underlying embryo hatching in a mouse model

Abstract:

Mammalian embryo hatching from the zona pellucida (ZP) is a prerequisite to undergo subsequent implantation, but little is known about the involved molecules and regulatory mechanisms underlying the hatching process. Hatching failure can lead to implantation failure. Clinical laboratories have developed the non-contact infra-red diode laser to manipulate ZP for various purpose, such as assist embryo hatching and facilitate embryo biopsy procedure. Previous studies attempted to investigate the...

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Division:
MSD
Department:
Women's & Reproductive Health
Oxford college:
St Cross College
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Women's & Reproductive Health
Sub department:
Women's & Reproductive Health
Role:
Contributor
Institution:
University of Oxford
Division:
MSD
Department:
Women's & Reproductive Health
Sub department:
Women's & Reproductive Health
Role:
Supervisor
ORCID:
0000-0003-3577-4041
Institution:
University of Oxford
Division:
MSD
Department:
Women's & Reproductive Health
Sub department:
Women's & Reproductive Health
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
Women's & Reproductive Health
Sub department:
Women's & Reproductive Health
Role:
Examiner
Institution:
University of Kent
Role:
Examiner
More from this funder
Name:
China Scholarship Council
Funder identifier:
http://dx.doi.org/10.13039/501100004543
Funding agency for:
Liu, Y
Grant:
201808060120
Programme:
Chinese government scholarship
More from this funder
Name:
Rosetrees Trust
Funder identifier:
http://dx.doi.org/10.13039/501100000833
Funding agency for:
Jones, C
Coward, K
Grant:
CM541
Programme:
Refining infra-red laser applications to facilitate embryo implantation in assisted reproductive technology
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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