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Catechol-O-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex

Abstract:

The Val 158 Met polymorphism of the human catechol-O-methyltransferase (COMT) gene affects activity of the enzyme and influences performance and efficiency of the prefrontal cortex (PFC); however, although catecholaminergic neurotransmission is implicatedm the underlying mechanisms remain elusive because studies of the role of COMT in PFC function are sparse. This study investigated the effect of tolcapone, a brain-penetrant COMT inhibitor, on a rat model of attentional set shifting, which is...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Tunbridge, E
Publisher:
Society for Neuroscience
Journal:
Journal of Neuroscience More from this journal
Volume:
24
Issue:
23
Pages:
5331–5335
Publication date:
2004-06-01
DOI:
EISSN:
1529-2401
Language:
English
Keywords:
Subjects:
UUID:
uuid:2116fa24-71fb-4371-901c-93b314c9a695
Local pid:
ora:1445
Deposit date:
2008-03-14

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