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Protein-lipid interactions and non-lamellar lipidic structures in membrane pore formation and membrane fusion

Abstract:

Pore-forming proteins and peptides act on their targeted lipid bilayer membranes to increase permeability. This approach to the modulation of biological function is relevant to a great number of living processes, including; infection, parasitism, immunity, apoptosis, development and neurodegeneration. While some pore-forming proteins/peptides assemble into rings of subunits to generate discrete, well-defined pore-forming structures, an increasing number is recognised to form pores via mechani...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.bbamem.2015.11.026

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Biology
Role:
Author
Publisher:
Elsevier Publisher's website
Journal:
Biochimica et Biophysica Acta (BBA) - Biomembranes Journal website
Volume:
1858
Issue:
3
Pages:
487-499
Publication date:
2015-12-02
DOI:
EISSN:
1879-2642
ISSN:
0005-2736
URN:
uuid:2106b372-d26d-41e2-bfb5-95a3a5427aeb
Source identifiers:
580658
Local pid:
pubs:580658

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