Journal article
Patterns of tree nut sensitization and allergy in the first 6 years of life in a population-based cohort
- Abstract:
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Introduction
Longitudinal population-based data regarding tree nut allergy are limited
Objectives
To determine population prevalence of tree nut allergy at age 6 years, and explore the relationship between egg and peanut allergy at age 1 year and development of tree nut allergy at age 6 years.
Methods
A population-based sample of 5,276 children were recruited at age one and followed up at age 6 years. At age 1 allergy to egg and peanut were determined by oral food challenge and parents reported their child’s history of reaction to tree nuts. Challenge-confirmed tree nut allergy was assessed at age 6.
Results
At age 1, prevalence of parent-reported tree nut allergy was 0.1% (95% CI 0.04-0.2). Only 18.5% of infants had consumed tree nuts in the first year of life. At age 6, challenge-confirmed tree nut allergy prevalence was 3.3% (95%CI 2.8-4.0), with cashew the most common (2.7%, 95% CI 2.2-3.3).
Of children with peanut allergy only at age 1, 27% (95%CI 16.1-39.7) were tree nut allergic at age 6, compared with 14% (95%CI 10.4-17.9) of those with egg allergy only and 37% (95%CI 27.2-47.4) of those with both peanut and egg allergy.
Conclusions
Tree nut allergy is uncommon in the first year of life, likely due to limited tree nut consumption. At age 6 years, tree nut allergy prevalence is similar to peanut allergy prevalence. Over a third of children with both peanut and egg allergy in infancy have tree nut allergy at age 6. Understanding how to prevent tree nut allergy should be an urgent priority for future research.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 3.5MB, Terms of use)
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- Publisher copy:
- 10.1016/j.jaci.2018.07.038
Authors
- Publisher:
- Elsevier
- Journal:
- Journal of Allergy and Clinical Immunology More from this journal
- Volume:
- 143
- Issue:
- 2
- Pages:
- 644-650.e5
- Publication date:
- 2018-08-30
- Acceptance date:
- 2018-07-10
- DOI:
- EISSN:
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1097-6825
- ISSN:
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0091-6749
- Keywords:
- Pubs id:
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pubs:927566
- UUID:
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uuid:20f39afb-84e1-4285-84f0-6daad3235148
- Local pid:
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pubs:927566
- Source identifiers:
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927566
- Deposit date:
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2018-11-15
Terms of use
- Copyright holder:
- American Academy of Allergy, Asthma and Immunology
- Copyright date:
- 2018
- Notes:
- © 2018 American Academy of Allergy, Asthma and Immunology. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: 10.1016/j.jaci.2018.07.038
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