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Implications of reducing antibiotic treatment duration for antimicrobial resistance in hospital settings: A modelling study and meta-analysis

Abstract:

Background: Reducing antibiotic treatment duration is a key component of hospital antibiotic stewardship interventions. However, its effectiveness in reducing antimicrobial resistance is uncertain and a clear theoretical rationale for the approach is lacking. In this study, we sought to gain a mechanistic understanding of the relation between antibiotic treatment duration and the prevalence of colonisation with antibiotic-resistant bacteria in hospitalised patients.

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pmed.1004013

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Oxford college:
St Hugh's College
Role:
Author
ORCID:
0000-0002-0216-9550
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Oxford college:
Worcester College
Role:
Author
ORCID:
0000-0001-8490-2930
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Oxford college:
Wolfson College
Role:
Author
ORCID:
0000-0003-2555-6980
More by this author
Role:
Author
ORCID:
0000-0002-6751-4124
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0002-9445-7217



Publisher:
Public Library of Science
Journal:
PLoS Medicine More from this journal
Volume:
20
Issue:
6
Article number:
e1004013
Publication date:
2023-06-15
Acceptance date:
2022-10-17
DOI:
EISSN:
1549-1676
ISSN:
1549-1277


Language:
English
Keywords:
Pubs id:
1464118
Local pid:
pubs:1464118
Deposit date:
2023-06-22

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