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Complement inhibitor of C5 activation from the soft tick Ornithodoros moubata.

Abstract:

Blood-feeding ticks must control C activation or be damaged by the host inflammatory response. We report the characterization and expression of a novel, relatively small, broad-acting C inhibitory protein (termed OmCI) from the soft tick Ornithodoros moubata. The native 17-kDa nonglycosylated protein inhibits both human and guinea pig classical and alternative C activation pathways. The IC50 values for each pathway were 12 and 27 nM, respectively, in hemolytic assays using human serum diluted...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.174.4.2084

Authors


Paesen, GC More by this author
Adamson, S More by this author
Lissina, O More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
174
Issue:
4
Pages:
2084-2091
Publication date:
2005-02-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:20ed82b4-7ad8-4971-9e8e-448d54c34e05
Source identifiers:
280133
Local pid:
pubs:280133

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