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Electrospun fibrous scaffolds for tissue engineering: Viewpoints on architecture and fabrication

Abstract:
Electrospinning has been used for the fabrication of extracellular matrix (ECM)-mimicking fibrous scaffolds for several decades. Electrospun fibrous scaffolds provide nanoscale/microscale fibrous structures with interconnecting pores, resembling natural ECM in tissues, and showing a high potential to facilitate the formation of artificial functional tissues. In this review, we summarize the fundamental principles of electrospinning processes for generating complex fibrous scaffold geometries that are similar in structural complexity to the ECM of living tissues. Moreover, several approaches for the formation of three-dimensional fibrous scaffolds arranged in hierarchical structures for tissue engineering are also presented.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3390/ijms19030745

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Oxford college:
Wolfson College
Role:
Author
ORCID:
0000-0001-6870-1485
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Oxford college:
St Catherine's College
Role:
Author


Publisher:
MDPI
Journal:
International Journal of Molecular Sciences More from this journal
Volume:
19
Issue:
3
Pages:
745
Publication date:
2018-03-06
Acceptance date:
2018-03-03
DOI:
EISSN:
1422-0067
ISSN:
1422-0067
Pmid:
29509688


Language:
English
Keywords:
Pubs id:
pubs:828603
UUID:
uuid:20afcf08-6bc1-4b9c-a6f4-86864bf03ae4
Local pid:
pubs:828603
Source identifiers:
828603
Deposit date:
2018-06-12

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