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Cerebral heme oxygenase 1 and 2 spatial distribution is modulated following injury from hypoxia-ischemia and middle cerebral artery occlusion in rats.

Abstract:

The regional and cellular distribution of heme oxygenase (HO)-1 and -2 following cerebral ischemia has not been ascertained. Employing the transient middle cerebral artery occlusion (MCAO) and hypoxia-ischemia (HI) models of unilateral brain injury, the aim was to elucidate immunolocalization of HO-1 and HO-2. Animals were sacrificed 3 days post-ischemia and immunohistochemistry and Western blotting were utilized to determine HO-1 and HO-2 expression. In the ipsilateral hemisphere following H...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford
Rahman, RM More by this author
Clarkson, AN More by this author
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Journal:
Neuroscience research
Volume:
65
Issue:
4
Pages:
326-334
Publication date:
2009-12-05
DOI:
EISSN:
1872-8111
ISSN:
0168-0102
URN:
uuid:206df245-5c88-44df-a51f-f372c576144c
Source identifiers:
347998
Local pid:
pubs:347998

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