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Phase Ia clinical evaluation of the plasmodium falciparum blood-stage antigen MSP1 in ChAd63 and MVA vaccine vectors

Abstract:

Efficacy trials of antibody-inducing protein-in-adjuvant vaccines targeting the blood-stage Plasmodium falciparum malaria parasite have so far shown disappointing results. The induction of cell-mediated responses in conjunction with antibody responses is thought to be one alternative strategy that could achieve protective efficacy in humans. Here, we prepared chimpanzee adenovirus 63 (ChAd63) and modified vaccinia virus Ankara (MVA) replication-deficient vectors encoding the well-studied P. f...

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Publisher copy:
10.1038/mt.2011.176

Authors


Sheehy, SH More by this author
Duncan, CJA More by this author
Collins, KA More by this author
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Journal:
Molecular Therapy
Volume:
19
Issue:
12
Pages:
2269-2276
Publication date:
2011-12-05
DOI:
EISSN:
1525-0024
ISSN:
1525-0016
URN:
uuid:205f2ace-2179-4a1d-83eb-1679e3d919ae
Source identifiers:
329426
Local pid:
pubs:329426
Language:
English

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