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Multiple transcript cleavage precedes polymerase release in termination by RNA polymerase II.

Abstract:

The requirement of poly(A) signals to elicit transcription termination of RNA polymerase II (pol II) is firmly established. However, little else is known about the actual process of pol II transcription termination. Evidence presented in this paper, based on analysis of nascent transcripts of the human beta- and epsilon-globin genes, demonstrates that pol II transcription termination involves two distinct and temporally separate events. The first event, termed pretermination cleavage (PTC), i...

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Publication status:
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Cell
Volume:
105
Issue:
5
Pages:
669-681
Publication date:
2001-06-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:205841a7-6b90-4a95-9389-93391f5534d5
Source identifiers:
19692
Local pid:
pubs:19692

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