Journal article : Review
Oocyte activation deficiency and assisted oocyte activation: mechanisms, obstacles and prospects for clinical application
- Abstract:
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BACKGROUND Oocyte activation deficiency (OAD) is attributed to the majority of cases underlying failure of ICSI cycles, the standard treatment for male factor infertility. Oocyte activation encompasses a series of concerted events, triggered by sperm-specific phospholipase C zeta (PLCζ), which elicits increases in free cytoplasmic calcium (Ca2+) in spatially and temporally specific oscillations. Defects in this specific pattern of Ca2+ release are directly attributable to mo... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.2MB, Terms of use)
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- Publisher copy:
- 10.1093/hropen/hoac003
Authors
- Publisher:
- European Society of Human Reproduction and Embryology
- Journal:
- Human Reproduction Open More from this journal
- Volume:
- 2022
- Issue:
- 2
- Pages:
- 1-29
- Publication date:
- 2022-02-07
- Acceptance date:
- 2022-01-28
- DOI:
- EISSN:
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2399-3529
- Pmid:
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35261925
- Language:
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English
- Keywords:
- Subtype:
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Review
- Pubs id:
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1246946
- Local pid:
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pubs:1246946
- Deposit date:
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2022-03-28
- ARK identifier:
Terms of use
- Copyright holder:
- Kashir et al
- Copyright date:
- 2022
- Rights statement:
- © The Author(s) 2022. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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