Journal article

Ex vivo hematopoietic stem cell expansion technologies: recent progress, applications, and open questions

Abstract:: Hematopoietic stem cells (HSCs) are a rare but potent cell type that support life-long hematopoiesis and will stably regenerate the entire blood and immune system following transplantation. HSC transplantation represents a mainstay treatment for various diseases of the blood and immune systems. The ex vivo expansion and manipulation of HSCs therefore represents an important approach to ask biological questions in experimental hematology and to help improve clinical HSC transplantation therapies. However, it has remained challenging to expand transplantable HSCs ex vivo. This review summarizes recent progress in ex vivo HSC expansion technologies and their applications to biological and clinical problems, and discusses current questions in the field.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Meaker, G., & Wilkinson, A. (2023). Ex vivo hematopoietic stem cell expansion technologies: recent progress, applications, and open questions. Experimental Hematology, 130.

MLA Style

Meaker, G., and A. Wilkinson. “Ex Vivo Hematopoietic Stem Cell Expansion Technologies: Recent Progress, Applications, and Open Questions.” Experimental Hematology, vol. 130, Elsevier, 2023.

Chicago Style

Meaker, G, and A Wilkinson. 2023. “Ex Vivo Hematopoietic Stem Cell Expansion Technologies: Recent Progress, Applications, and Open Questions.” Experimental Hematology 130.
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Files:: Meaker_Wilkinson_2024_Ex_vivo_hematopoietic.pdf

(Preview, Version of record, pdf, 548.8KB, Terms of use)

Publisher copy:: 10.1016/j.exphem.2023.12.001

Authors

+ Meaker, G More by this author

Institution:: University of Oxford
Division:: MSD
Department:: RDM
Sub department:: Weatherall Insti. of Molecular Medicine
Role:: Author

+ Wilkinson, A More by this author

Institution:: University of Oxford
Division:: MSD
Department:: RDM
Sub department:: Weatherall Insti. of Molecular Medicine
Role:: Author
ORCID:: 0000-0001-7406-0151

+ Kay Kendall Leukaemia Fund More from this funder

Grant:: KKL1378

+ John Fell Fund More from this funder

Publisher:: Elsevier
Journal:: Experimental Hematology More from this journal
Volume:: 130
Article number:: 104136
Publication date:: 2023-12-09
Acceptance date:: 2023-12-05
DOI:: 10.1016/j.exphem.2023.12.001
ISSN:: 0301-472X

Language:: English
Keywords:: stem cell transplantation

FFR

CRISPR

ex vivo

self-renewal

Hematopoietic stem cell

gene therapy

expansion
Pubs id:: 1577871
Local pid:: pubs:1577871
Deposit date:: 2023-12-06

Terms of use

Copyright holder:: ISEH
Copyright date:: 2023
Rights statement:: © 2023 ISEH – Society for Hematology and Stem Cells. Published by Elsevier Inc. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/)

Licence:: CC Attribution (CC BY)

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