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Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9.

Abstract:

The apoptosome, a heptameric complex of Apaf-1, cytochrome c, and caspase-9, has been considered indispensable for the activation of caspase-9 during apoptosis. By using a large panel of genetically modified murine embryonic fibroblasts, we show here that, in response to tumor necrosis factor (TNF), caspase-8 cleaves and activates caspase-9 in an apoptosome-independent manner. Interestingly, caspase-8-cleaved caspase-9 induced lysosomal membrane permeabilization but failed to activate the eff...

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Publisher copy:
10.1128/mcb.00716-06

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine
Role:
Author
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Journal:
Molecular and cellular biology
Volume:
26
Issue:
21
Pages:
7880-7891
Publication date:
2006-11-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:2016f36b-951e-40a4-b962-e156f4c1c0f5
Source identifiers:
429222
Local pid:
pubs:429222

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