Journal article
Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9.
- Abstract:
-
The apoptosome, a heptameric complex of Apaf-1, cytochrome c, and caspase-9, has been considered indispensable for the activation of caspase-9 during apoptosis. By using a large panel of genetically modified murine embryonic fibroblasts, we show here that, in response to tumor necrosis factor (TNF), caspase-8 cleaves and activates caspase-9 in an apoptosome-independent manner. Interestingly, caspase-8-cleaved caspase-9 induced lysosomal membrane permeabilization but failed to activate the eff...
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- Publisher copy:
- 10.1128/mcb.00716-06
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Authors
Bibliographic Details
- Journal:
- Molecular and cellular biology
- Volume:
- 26
- Issue:
- 21
- Pages:
- 7880-7891
- Publication date:
- 2006-11-01
- DOI:
- EISSN:
-
1098-5549
- ISSN:
-
0270-7306
- Source identifiers:
-
429222
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:429222
- UUID:
-
uuid:2016f36b-951e-40a4-b962-e156f4c1c0f5
- Local pid:
- pubs:429222
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2006
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