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Common west African HLA antigens are associated with protection from severe malaria.

Abstract:

A large case-control study of malaria in West African children shows that a human leucocyte class I antigen (HLA-Bw53) and an HLA class II haplotype (DRB1*1302-DQB1*0501), common in West Africans but rare in other racial groups, are independently associated with protection from severe malaria. In this population they account for as great a reduction in disease incidence as the sickle-cell haemoglobin variant. These data support the hypothesis that the extraordinary polymorphism of major histo...

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Publication status:
Published

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Publisher copy:
10.1038/352595a0

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Allsopp, CE More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Anstey, NM More by this author
Twumasi, P More by this author
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Journal:
Nature
Volume:
352
Issue:
6336
Pages:
595-600
Publication date:
1991-08-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:1fc14320-a171-4174-a273-f33937bc5598
Source identifiers:
34327
Local pid:
pubs:34327

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