Journal article
Detection of alpha-synuclein conformational variants from gastro-intestinal biopsy tissue as a potential biomarker for Parkinson's disease
- Abstract:
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Aims
Gastrointestinal (GI) a-synuclein (aSyn) detection as a potential biomarker of Parkinson’s disease (PD) is challenged by conflicting results of recent studies. To increase sensitivity and specificity, we applied three techniques to detect different conformations of aSyn in GI biopsies obtained from a longitudinal, clinically wellcharacterized cohort of PD patients and healthy controls (HC).
Methods
With immunohistochemistry (IHC), we used antibodies reactive ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.1MB, Terms of use)
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- Publisher copy:
- 10.1111/nan.12486
Authors
Funding
Bibliographic Details
- Publisher:
- Wiley
- Journal:
- Neuropathology and Applied Neurobiology More from this journal
- Volume:
- 44
- Issue:
- 7
- Pages:
- 722-736
- Publication date:
- 2018-04-19
- Acceptance date:
- 2018-04-02
- DOI:
- EISSN:
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1365-2990
- ISSN:
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0305-1846
- Pmid:
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29676021
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:846009
- UUID:
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uuid:1fb2ee7e-901f-455e-8986-2701fadd7dd8
- Local pid:
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pubs:846009
- Deposit date:
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2018-05-30
Terms of use
- Copyright holder:
- Parkkinen et al
- Copyright date:
- 2018
- Notes:
- © 2018 The Authors. Neuropathology and Applied Neurobiology published by John Wiley and Sons Ltd on behalf of British Neuropathological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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