Journal article
The role of MLH1, MSH2 and MSH6 in the development of colorectal cancer in Uganda
- Abstract:
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Introduction: In Uganda, colorectal cancer (CRC) is steadily increasing according to the Kampala Cancer Registry. In the West, microsatellite instability is detected in 90% of hereditary nonpolyposis colon cancers (HNPCC) which account for 1–2% of all CRC, and 15% of sporadic CRC. Germline mutations in MLH1 and MSH2 account for 90% of HNPCC in the West, whilst the remainder of cases are due to mutations in MSH6 and PMS2. The aim of this study was to determine the microsatellite instability (M...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.5MB, Terms of use)
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- Publisher copy:
- 10.1186/s12885-025-14195-9
Authors
- Publisher:
- BioMed Central
- Journal:
- BMC Cancer More from this journal
- Volume:
- 25
- Issue:
- 1
- Article number:
- 792
- Publication date:
- 2025-04-28
- Acceptance date:
- 2025-04-21
- DOI:
- EISSN:
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1471-2407
- Language:
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English
- Keywords:
- Source identifiers:
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2896276
- Deposit date:
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2025-04-28
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