The Effects of Varying Intensities of Unilateral Handgrip Fatigue on Bilateral Movement

Journal article

Background/Objectives: The ability to maintain movement quality despite muscle fatigue is essential for daily activities and preserving independence after motor impairments. Many real-life situations involve asymmetrical muscle activation, leading to unilateral muscle fatigue. Repeated unilateral handgrip contractions at submaximal force have been linked to neural changes in both contralateral and ipsilateral motor areas, as well as improved contralateral response times in a button-press task. However, it remains unclear whether these improvements in response latency extend to higher-level benefits in overall arm movement quality. Methods: Thirty healthy participants performed unilateral handgrip fatiguing tasks at 5%, 50%, and 75% of maximum voluntary contraction (MVC) force. Subsequently, bilateral upper-limb movement quality was assessed in an object-hit task using a Kinarm robot. Results: The 50% and 75% MVC protocols elicited muscle fatigue as evidenced by declines in force output, post-exercise MVC, electromyography magnitude changes, and increased perceived exertion compared to the 5% MVC control condition. However, no significant changes in kinematic measures of the object-hit task were observed for either the fatigued (ipsilateral) or non-fatigued (contralateral) arm, indicating that unilateral handgrip fatigue did not affect higher-level movement quality. Conclusions: Previously reported improvements on contralateral response latency in a button-press task were not found to translate into advanced arm movement quality benefits.

Authors: Knorz, AL; Andrushko, JW; Sporn, S; Stagg, CJ; Zich, C

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: MDPI
• Journal: Brain Sciences
• Volume: 16
• Issue: 1
• Pages: 47
• Article number: 47
• Publication date: 2025-12-29
• Acceptance date: 2025-12-25
• DOI: 10.3390/brainsci16010047
• EISSN: 2076-3425
• ISSN: 2076-3425
• Language: English
• Keywords: motor control; contralateral adaptation; muscle fatigue; motor learning; kinematic assessment