Journal article icon

Journal article

Discovery of orally bioavailable, quinoline-based aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with potent cellular activity

Abstract:

Aldehyde dehydrogenases (ALDHs) are responsible for the metabolism of aldehydes (exogenous and endogenous) and possess vital physiological and toxicological functions in areas such as CNS, inflammation, metabolic disorders, and cancers. Overexpression of certain ALDHs (e.g. ALDH1A1) are important biomarkers in cancers and cancer stem cells (CSCs) indicating the potential need for the identification and development of small molecule ALDH inhibitors. Herein, a newly designed series of quinoline...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1021/acs.jmedchem.8b00270

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
Expand authors...
More from this funder
Grant:
AA022057 (V.V.) and AA021724 (V.V.)
Cancer Research UK More from this funder
Rosetrees Foundation More from this funder
Publisher:
American Chemical Society Publisher's website
Journal:
Journal of Medicinal Chemistry Journal website
Volume:
61
Issue:
11
Pages:
4883–4903
Publication date:
2018-05-16
DOI:
EISSN:
1520-4804
ISSN:
0022-2623
Pubs id:
pubs:848003
URN:
uri:1f809b93-0ea0-4d5d-bdc2-7e84d338e1fc
UUID:
uuid:1f809b93-0ea0-4d5d-bdc2-7e84d338e1fc
Local pid:
pubs:848003

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP