- Abstract:
-
Aldehyde dehydrogenases (ALDHs) are responsible for the metabolism of aldehydes (exogenous and endogenous) and possess vital physiological and toxicological functions in areas such as CNS, inflammation, metabolic disorders, and cancers. Overexpression of certain ALDHs (e.g. ALDH1A1) are important biomarkers in cancers and cancer stem cells (CSCs) indicating the potential need for the identification and development of small molecule ALDH inhibitors. Herein, a newly designed series of quinoline...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 5.3MB)
-
- Publisher copy:
- 10.1021/acs.jmedchem.8b00270
-
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- Publisher:
- American Chemical Society Publisher's website
- Journal:
- Journal of Medicinal Chemistry Journal website
- Volume:
- 61
- Issue:
- 11
- Pages:
- 4883–4903
- Publication date:
- 2018-05-16
- DOI:
- EISSN:
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1520-4804
- ISSN:
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0022-2623
- Pubs id:
-
pubs:848003
- URN:
-
uri:1f809b93-0ea0-4d5d-bdc2-7e84d338e1fc
- UUID:
-
uuid:1f809b93-0ea0-4d5d-bdc2-7e84d338e1fc
- Local pid:
- pubs:848003
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Journal article
Discovery of orally bioavailable, quinoline-based aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with potent cellular activity
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Cancer Research UK
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Rosetrees Foundation
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