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BRD4 promotes p63 and GRHL3 expression downstream of FOXO in mammary epithelial cells

Abstract:

Bromodomain-containing protein 4 (BRD4) is a member of the bromo- and extraterminal (BET) domain-containing family of epigenetic readers which is under intensive investigation as a target for anti-tumor therapy. BRD4 plays a central role in promoting the expression of select subsets of genes including many driven by oncogenic transcription factors and signaling pathways. However, the role of BRD4 and the effects of BET inhibitors in non-transformed cells remain mostly unclear. We demonstrate ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkw1276

Authors


Nagarajan, S More by this author
Hamdan, FH More by this author
More by this author
ORCID:
0000-0003-0853-0770
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German Academic Exchange Service More from this funder
Erasmus Mundus External Cooperation Window More from this funder
Gottingen Graduate School for Neurosciences, Biophysics and Molecular Biosciences More from this funder
China Scholarship Council More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
45
Issue:
6
Pages:
3130-3145
Publication date:
2016-12-15
Acceptance date:
2016-12-09
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Pubs id:
pubs:666490
URN:
uri:1f5ce371-7643-4cd2-a466-5d39bac395de
UUID:
uuid:1f5ce371-7643-4cd2-a466-5d39bac395de
Local pid:
pubs:666490

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