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Cytotoxic T cells recognize fragments of the influenza nucleoprotein.

Abstract:

Recent work has shown that a major population of murine influenza A specific cytotoxic T lymphocytes (CTL) recognize the viral nucleoprotein. In order to investigate the mechanism by which this nonglycoprotein component of the virus is recognized by CTL, a series of deletion mutants of an A virus NP gene were studied. The results showed that CTL recognize three distinct epitopes of the NP molecule. Both N- and C-terminal fragments of the protein are transported, independently of each other, t...

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Journal:
Cell More from this journal
Volume:
42
Issue:
2
Pages:
457-467
Publication date:
1985-09-01
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Language:
English
Keywords:
Pubs id:
pubs:95901
UUID:
uuid:1f5a3acb-2bf3-472a-8e12-1f6ac06b8a33
Local pid:
pubs:95901
Source identifiers:
95901
Deposit date:
2012-12-19

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