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Cytotoxic T cells recognize fragments of the influenza nucleoprotein.

Abstract:

Recent work has shown that a major population of murine influenza A specific cytotoxic T lymphocytes (CTL) recognize the viral nucleoprotein. In order to investigate the mechanism by which this nonglycoprotein component of the virus is recognized by CTL, a series of deletion mutants of an A virus NP gene were studied. The results showed that CTL recognize three distinct epitopes of the NP molecule. Both N- and C-terminal fragments of the protein are transported, independently of each other, t...

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Journal:
Cell
Volume:
42
Issue:
2
Pages:
457-467
Publication date:
1985-09-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:1f5a3acb-2bf3-472a-8e12-1f6ac06b8a33
Source identifiers:
95901
Local pid:
pubs:95901

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