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Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.

Abstract:

Tetrahydrobiopterin (BH4) is a required cofactor for the synthesis of NO by endothelial nitric oxide synthase (eNOS), and endothelial BH4 bioavailability is a critical factor in regulating the balance between NO and superoxide production (eNOS coupling). Biosynthesis of BH4 is determined by the activity of GTP-cyclohydrolase I (GTPCH). However, BH4 levels may also be influenced by oxidation, forming 7,8-dihydrobiopterin (BH2), which promotes eNOS uncoupling. Conversely, dihydrofolate reductas...

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Publication status:
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
Journal:
Free radical biology and medicine More from this journal
Volume:
50
Issue:
11
Pages:
1639-1646
Publication date:
2011-06-01
DOI:
EISSN:
1873-4596
ISSN:
0891-5849
Language:
English
Keywords:
Pubs id:
pubs:124359
UUID:
uuid:1f4a410d-4061-491e-bc7f-6d874750c0db
Local pid:
pubs:124359
Source identifiers:
124359
Deposit date:
2012-12-19

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