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Asymmetric synthesis of (+)-negamycin

Abstract:
(+)-Negamycin was synthesised employing the highly diastereoselective conjugate addition of lithium (α-methylbenzyl)benzylamide in the key step. The synthesis was completed in 13 steps starting from ethyl 4-chloroacetoacetate with an overall yield of 24%.
Publication status:
Published

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
TETRAHEDRON-ASYMMETRY More from this journal
Volume:
7
Issue:
7
Pages:
1919-1922
Publication date:
1996-07-01
DOI:
ISSN:
0957-4166
Pubs id:
pubs:110841
UUID:
uuid:1f49aab1-ff87-4a10-9862-2549ba9a7666
Local pid:
pubs:110841
Source identifiers:
110841
Deposit date:
2012-12-19

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