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Methylene blue-mediated hexose monophosphate shunt stimulation in human red blood cells in vitro: independence from intracellular oxidative injury.

Abstract:

The red blood cell hexose monophosphate shunt (HMS) and proteolytic responses to several concentrations of Methylene Blue or sodium nitrite were measured. The results suggested two distinct mechanisms for activation of the HMS: (1) nitrite treatment increased HMS activity in response to oxidative challenge to red cell protein; (2) Methylene Blue treatment activated HMS without injurious oxidative challenge. Nitrite-treated cells actively degraded protein, whereas Methylene Blue-treated red ce...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Journal:
International journal of biochemistry
Volume:
16
Issue:
10
Pages:
1053-1058
Publication date:
1984-01-01
DOI:
ISSN:
0020-711X
Source identifiers:
81733
Language:
English
Keywords:
Pubs id:
pubs:81733
UUID:
uuid:1f44d91c-5fe2-4074-9217-61933a0b4559
Local pid:
pubs:81733
Deposit date:
2012-12-19

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