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Journal article

Synthetic lethal vulnerabilities of cancer.

Abstract:

The great majority of targeted anticancer drugs inhibit mutated oncogenes that display increased activity. Yet many tumors do not contain such actionable aberrations, such as those harboring loss-of-function mutations. The notion of targeting synthetic lethal vulnerabilities in cancer cells has provided an alternative approach to exploiting more of the genetic and epigenetic changes acquired during tumorigenesis. Here, we review synthetic lethality as a therapeutic concept that exploits the i...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
Journal:
Annual review of pharmacology and toxicology
Volume:
55
Issue:
1
Pages:
513-531
Publication date:
2015-01-01
DOI:
EISSN:
1545-4304
ISSN:
0362-1642
Source identifiers:
490919

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