Journal article
Synthetic lethal vulnerabilities of cancer.
- Abstract:
-
The great majority of targeted anticancer drugs inhibit mutated oncogenes that display increased activity. Yet many tumors do not contain such actionable aberrations, such as those harboring loss-of-function mutations. The notion of targeting synthetic lethal vulnerabilities in cancer cells has provided an alternative approach to exploiting more of the genetic and epigenetic changes acquired during tumorigenesis. Here, we review synthetic lethality as a therapeutic concept that exploits the i...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Annual review of pharmacology and toxicology
- Volume:
- 55
- Issue:
- 1
- Pages:
- 513-531
- Publication date:
- 2015-01-01
- DOI:
- EISSN:
-
1545-4304
- ISSN:
-
0362-1642
- Source identifiers:
-
490919
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:490919
- UUID:
-
uuid:1f43e649-e34c-4f7d-8394-9429681bf0b1
- Local pid:
- pubs:490919
- Deposit date:
- 2014-11-22
Terms of use
- Copyright date:
- 2015
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