Journal article icon

Journal article

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity

Abstract:

Most tumours have an aberrantly activated lipid metabolism1,2 that enables them to synthesize, elongate and desaturate fatty acids to support proliferation. However, only particular subsets of cancer cells are sensitive to approaches that target fatty acid metabolism and, in particular, fatty acid desaturation3. This suggests that many cancer cells contain an unexplored plasticity in their fatty acid metabolism. Here we show that some cancer cells can exploit an alternative fatty acid desatur...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/s41586-019-0904-1

Authors


Expand authors...
Publisher:
Springer Nature Publisher's website
Journal:
Nature Journal website
Volume:
566
Pages:
403-406
Publication date:
2019-02-06
Acceptance date:
2018-12-20
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Pmid:
30728499
Source identifiers:
969653
Language:
English
Pubs id:
pubs:969653
UUID:
uuid:1f3c3874-78ab-474c-91a8-49145a178693
Local pid:
pubs:969653
Deposit date:
2019-02-12

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP