Journal article
Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity
- Abstract:
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Most tumours have an aberrantly activated lipid metabolism1,2 that enables them to synthesize, elongate and desaturate fatty acids to support proliferation. However, only particular subsets of cancer cells are sensitive to approaches that target fatty acid metabolism and, in particular, fatty acid desaturation3. This suggests that many cancer cells contain an unexplored plasticity in their fatty acid metabolism. Here we show that some cancer cells can exploit an alternative fatty acid desatur...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 326.6KB)
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- Publisher copy:
- 10.1038/s41586-019-0904-1
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Authors
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Journal website
- Volume:
- 566
- Pages:
- 403-406
- Publication date:
- 2019-02-06
- Acceptance date:
- 2018-12-20
- DOI:
- EISSN:
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1476-4687
- ISSN:
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0028-0836
- Pmid:
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30728499
- Source identifiers:
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969653
Item Description
- Language:
- English
- Pubs id:
-
pubs:969653
- UUID:
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uuid:1f3c3874-78ab-474c-91a8-49145a178693
- Local pid:
- pubs:969653
- Deposit date:
- 2019-02-12
Terms of use
- Copyright holder:
- Vriens et al
- Copyright date:
- 2019
- Notes:
- © The Author(s), under exclusive licence to Springer Nature Limited 2019. This is the accepted manuscript version of the article. The final version is available online from Springer Nature at: https://doi.org/10.1038/s41586-019-0904-1
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