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Identification and structural characterization of a sialylated lacto-N-neotetraose structure in the lipopolysaccharide of Haemophilus influenzae.

Abstract:

A sialylated lacto-N-neotetraose (Sial-lNnT) structural unit was identified and structurally characterized in the lipopolysaccharide (LPS) from the genome-sequenced strain Rd [corrected] (RM118) of the human pathogen Haemophilus influenzae grown in the presence of sialic acid. A combination of molecular genetics, MS and NMR spectroscopy techniques showed that this structural unit extended from the proximal heptose residue of the inner core region of the LPS molecule. The structure of the Sial...

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Publication status:
Published

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Journal:
European journal of biochemistry / FEBS
Volume:
269
Issue:
16
Pages:
4009-4019
Publication date:
2002-08-05
DOI:
EISSN:
1432-1033
ISSN:
0014-2956
URN:
uuid:1f310124-9922-4f3e-b694-ba4e8024031f
Source identifiers:
115619
Local pid:
pubs:115619

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