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Journal article

Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing.

Abstract:

This article outlines the need for a homeostatic response to alterations in cellular oxygenation. It describes work on erythropoietin control that led to the discovery of the hypoxia-inducible transcription factor (HIF-1) and the parallel recognition that this system was responsive to a widespread oxygen-sensing mechanism. Subsequently, multiple HIF isoforms have been shown to have overlapping but non-redundant functions, controlling expression of genes involved in diverse processes such as a...

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Publication status:
Published

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Publisher copy:
10.1007/s00018-009-0147-7

Authors


Coleman, ML More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, BHF Centre of Research Excellence
Journal:
Cellular and molecular life sciences : CMLS
Volume:
66
Issue:
22
Pages:
3539-3554
Publication date:
2009-11-05
DOI:
EISSN:
1420-9071
ISSN:
1420-682X
URN:
uuid:1f2c5ba0-58a1-4ef1-af38-d4b2f6cb2dcd
Source identifiers:
34889
Local pid:
pubs:34889

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