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Thesis

Computational studies of cell-penetrating peptides interactions with complex membranes models

Abstract:

Membrane active peptides with the ability to cross the plasma membrane represent a promising class of therapeutic compounds. However, translocation efficacy and membrane toxicity of these peptides appear correlated and a better understanding of their mechanisms of action is needed to achieve the desired effect. Here, a range of coarse grain molecular dynamics simulations have been performed to systematically investigate the interactions of such cell-penetrating peptides (CPPs) with biologi...

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Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
Institution:
University of Oxford
Research group:
SBCB
Oxford college:
Oriel College
Department:
Medical Sciences Division - Biochemistry
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:1f154de5-6073-4bc6-986a-397734f5f140
Local pid:
ora:11304

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