Thesis
Computational studies of cell-penetrating peptides interactions with complex membranes models
- Abstract:
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Membrane active peptides with the ability to cross the plasma membrane represent a promising class of therapeutic compounds. However, translocation efficacy and membrane toxicity of these peptides appear correlated and a better understanding of their mechanisms of action is needed to achieve the desired effect. Here, a range of coarse grain molecular dynamics simulations have been performed to systematically investigate the interactions of such cell-penetrating peptides (CPPs) with biologi...
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Authors
Contributors
+ Sansom, M
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
+ Deane, C
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
+ Milletti, F
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Funding
+ Engineering and Physical Sciences Research Council
More from this funder
Funding agency for:
Hélie, J
Bibliographic Details
- Publication date:
- 2014
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:1f154de5-6073-4bc6-986a-397734f5f140
- Local pid:
- ora:11304
- Deposit date:
- 2015-04-29
Terms of use
- Copyright holder:
- Jean Helie
- Copyright date:
- 2014
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