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Multicenter, Prospective, Randomized Controlled Trial of High-Sensitivity Cardiac Troponin I–Guided Combination Angiotensin Receptor Blockade and Beta-Blocker Therapy to Prevent Anthracycline Cardiotoxicity: The Cardiac CARE Trial

Abstract:

BACKGROUND AND AIMS: Cardiometabolic disorders include cardiovascular diseases and metabolic conditions such as diabetes mellitus and represent a leading cause of morbidity and mortality worldwide. Identification of specific biological pathways driving progression of these disorders may unveil targets for preventing and treating these diseases. Dysregulated myocardial and pancreatic beta-cell calcium handling may be a key mediator and driver of these disorders. Manganese is a calcium ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0003-4974-0344
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Role:
Author
ORCID:
0000-0001-6015-7841
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Role:
Author
ORCID:
0000-0003-4295-8885
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Role:
Author
ORCID:
0000-0001-9874-6211
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Role:
Author
ORCID:
0000-0002-0420-0136


Publisher:
Lippincott, Williams & Wilkins
Journal:
Circulation More from this journal
Volume:
148
Issue:
21
Pages:
1680-1690
Publication date:
2023-09-25
DOI:
EISSN:
1524-4539
ISSN:
0009-7322


Language:
English
Keywords:
Pubs id:
1536573
Local pid:
pubs:1536573
Source identifiers:
W4387002448
Deposit date:
2026-05-17
ARK identifier:
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