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Journal article

Modulation of thin filament activation by breakdown or isoform switching of thin filament proteins: physiological and pathological implications.

Abstract:

In the heart, the contractile apparatus is adapted to the specific demands of the organ for continuous rhythmic contraction. The specialized contractile properties of heart muscle are attributable to the expression of cardiac-specific isoforms of contractile proteins. This review describes the isoforms of the thin filament proteins actin and tropomyosin and the three troponin subunits found in human heart muscle, how the isoform profiles of these proteins change during development and disease...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
Journal:
Circulation research More from this journal
Volume:
93
Issue:
12
Pages:
1170-1178
Publication date:
2003-12-01
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
Language:
English
Keywords:
Pubs id:
pubs:104883
UUID:
uuid:1efc6af5-08b5-47fa-bb14-e2c160ff10ac
Local pid:
pubs:104883
Source identifiers:
104883
Deposit date:
2012-12-19

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