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Silk micrococoons for protein stabilisation and molecular encapsulation

Abstract:

Naturally spun silks generate fibres with unique properties, including strength, elasticity and biocompatibility. Here we describe a microfluidics-based strategy to spin liquid native silk, obtained directly from the silk gland of Bombyx mori silkworms, into micron-scale capsules with controllable geometry and variable levels of intermolecular b-sheet content in their protein shells. We demonstrate that such micrococoons can store internally the otherwise highly unstable liquid native silk fo...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/ncomms15902

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Department:
Oxford, MPLS, Zoology
Role:
Author
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Department:
Oxford, MPLS, Zoology
Role:
Author
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Elan Pharmaceuticals More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Pages:
15902
Publication date:
2017-07-05
Acceptance date:
2017-01-27
DOI:
EISSN:
2041-1723
Pubs id:
pubs:673549
URN:
uri:1efbaabd-4cb6-4d9b-9fbd-b177f8759479
UUID:
uuid:1efbaabd-4cb6-4d9b-9fbd-b177f8759479
Local pid:
pubs:673549

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