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Sleep down state-active ID2/Nkx2.1 interneurons in the neocortex

Abstract:

Pyramidal cells and GABAergic interneurons fire together in balanced cortical networks. In contrast to this general rule, we describe a distinct neuron type in mice and rats whose spiking activity is anti-correlated with all principal cells and interneurons in all brain states but, most prevalently, during the down state of non-REM (NREM) sleep. We identify these down state-active (DSA) neurons as deep-layer neocortical neurogliaform cells that express ID2 and Nkx2.1 and are weakly immunoreac...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41593-021-00797-6

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Oxford college:
New College
Role:
Author
ORCID:
0000-0001-6444-1188
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Role:
Author
ORCID:
0000-0001-8180-0816
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Name:
European Molecular Biology Organization (EMBO)
Publisher:
Springer Nature
Journal:
Nature Neuroscience More from this journal
Volume:
24
Issue:
3
Pages:
401–411
Publication date:
2021-02-22
Acceptance date:
2021-01-08
DOI:
EISSN:
1546-1726
ISSN:
1097-6256
Language:
English
Keywords:
Pubs id:
1165834
Local pid:
pubs:1165834
Deposit date:
2021-03-08

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