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Journal article

Exenatide decreases liver fat content and epicardial adipose tissue in patients with obesity and type 2 diabetes: a prospective randomized clinical trial using magnetic resonance imaging and spectroscopy.

Abstract:

Aim

To conduct a prospective randomized trial to investigate the effect of glucagon-like peptide-1 (GLP-1) analogues on ectopic fat stores.

Methods

A total of 44 obese subjects with type 2 diabetes uncontrolled on oral antidiabetic drugs were randomly assigned to receive exenatide or reference treatment according to French guidelines. Epicardial adipose tissue (EAT), myocardial triglyceride content (MTGC), hepatic triglyceride content (HTGC) and pancreatic triglyc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/dom.12680

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM, RDM Cardiovascular Medicine
Role:
Author
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Amylin Pharmaceuticals More from this funder
AstraZeneca More from this funder
Publisher:
Wiley Publisher's website
Journal:
Diabetes, Obesity & Metabolism Journal website
Volume:
18
Issue:
9
Pages:
882-891
Publication date:
2016-04-05
Acceptance date:
2015-04-20
DOI:
EISSN:
1462-8902
ISSN:
1463-1326
Pubs id:
pubs:680094
URN:
uri:1edcdb92-cd88-4e69-959e-52a9b3825d2c
UUID:
uuid:1edcdb92-cd88-4e69-959e-52a9b3825d2c
Local pid:
pubs:680094

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