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Journal article

Order and disorder in large multi-site docking proteins of the Gab family--implications for signalling complex formation and inhibitor design strategies.

Abstract:

Large multi-site docking (LMD) proteins of the Gab, IRS, FRS, DOK and Cas families consist of one or two folded N-terminal domains, followed by a predominantly disordered C-terminal extension. Their primary function is to provide a docking platform for signalling molecules (including PI3K, PLC, Grb2, Crk, RasGAP, SHP2) in intracellular signal transmission from activated cell-surface receptors, to which they become coupled. A detailed analysis of the structural nature and intrinsic disorder pr...

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Publication status:
Published

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Publisher copy:
10.1039/c1mb05272a

Authors


Journal:
Molecular bioSystems
Volume:
8
Issue:
1
Pages:
33-46
Publication date:
2012-01-01
DOI:
EISSN:
1742-2051
ISSN:
1742-206X
Source identifiers:
221549
Language:
English
Keywords:
Pubs id:
pubs:221549
UUID:
uuid:1ea9103f-2dac-48b6-a989-78548ea162bb
Local pid:
pubs:221549
Deposit date:
2012-12-19

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