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Engineering live cell surfaces with functional polymers via cytocompatible controlled radical polymerization

Abstract:

The capability to graft synthetic polymers onto the surfaces of live cells offers the potential to manipulate and control their phenotype and underlying cellular processes. Conventional grafting-to strategies for conjugating preformed polymers to cell surfaces are limited by low polymer grafting efficiency. Here we report an alternative grafting-from strategy for directly engineering the surfaces of live yeast and mammalian cells through cell surface-initiated controlled radical polymerizatio...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nchem.2713

Authors


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Role:
Author
ORCID:
0000-0002-5622-6362
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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemical Biology
Role:
Author
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US Army Research Office More from this funder
Garland Initiative More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Nature Chemistry Journal website
Volume:
9
Issue:
6
Pages:
537-545
Publication date:
2017-01-30
Acceptance date:
2016-11-30
DOI:
EISSN:
1755-4349
ISSN:
1755-4330
Source identifiers:
701235
Keywords:
Pubs id:
pubs:701235
UUID:
uuid:1ea0c65b-32f8-445c-a356-68b3056a7c0a
Local pid:
pubs:701235
Deposit date:
2018-03-11

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